Abnormalities of lymphocyte subsets in polymyositis.

bilateral pulmonary nodules. Histological examination of a biopsy sample of the thigh mass suggested synovial sarcoma. Because of the metastatic pulmonary lesions 150 mg doxorubicin was given by intravenous injection. Three days later the haemoglobin concentration fell suddenly to 10-6 g/dl (reticulocytes 4-1%'). Results of Coombs tests were negative. Supravital staining (cresyl blue) of a blood film showed numerous Heinz bodies. In addition, there was evidence of both haemoglobinaemia and haemoglobinuria. Over the next few days the haemoglobin concentration dropped to 9-2 gldl (9-80o reticulocytes), but three weeks later it had returned to 14-0 g/dl (2 1,' reticulocytes). At the patient's request no further chemotherapy was given, and he died three months after his initial presentation.